Vehicle-to-vehicle (V2V) technology has the potential to significantly enhance driver safety. The type, placement, and orientation of V2V antennas all affect the performance of the communication system. Simulation software for high frequency electromagnetics can be used to analyze the farfield effects of various vehicle antenna configurations without the need to perform physical testing. We present a simulation-based method for optimizing the placement and orientation of a monopole antenna on a vehicle using a Global Response Surface Method (GRSM).